What is a proteoform?

“Proteoform” is a label that captures all of the protein-based diversity that can come from a single gene.

“Proteoform” is a more specific term than “protein”

TRANSLATION

one gene

acts as the blueprint for…

several protein isoforms

which can be modified into…

POST-TRANSLATIONAL MODIFICATION

  • phosphorylation,

  • glycosylation,

  • acetylation,

  • methylation,

  • truncation,

    etc.

many proteoforms

Conventional proteomics looks at parts of proteins…

introducing ambiguity into biomarker measurement

many proteoforms

ANTIBODY ASSAY

DIGESTION

MEASURE

limited scope

But proteoforms are better biomarkers

than modifications or overall protein levels

In a study of liver transplant patients, two distinct Platelet Factor 4 proteoforms each pointed towards different transplant rejection states.

In a study of an Alzheimer’s Disease mouse model, Amyloid Beta proteoform changes correlated with key transition points in disease progression.

In a study of a cancer cell line model, MEK1 proteoform changes correlated with disease subtype and the drug used for treatment.

Want to unlock the power of proteoforms?

Whether you are a potential customer, collaborator, or co-developer, we are excited to hear from you about how we can help your next project.